Transport and Utilization of Glycogen Breakdown Products by Gardnerella spp. from the Human Vaginal Microbiome.

ABSTRACT: Multiple Gardnerella species frequently cooccur in vaginal microbiomes, and several factors, including competition for nutrients such as glycogen could determine their population structure. Although Gardnerella spp. can hydrolyze glycogen to produce glucose, maltose, maltotriose, and maltotetraose, how these sugars are transported and utilized for growth is unknown. We determined the distribution of genes encoding transporter proteins associated with the uptake of glucose, maltose, and malto-oligosaccharides and maltodextrins among Gardnerella species. A total of five different ABC transporters were identified in Gardnerella spp. of which MusEFGK₂I and MalXFGK were conserved across all 15 Gardnerella isolates. RafEFGK and TMSP (trehalose, malto

SUBMITTER: Bhandari P 

PROVIDER: S-EPMC10101108 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature