Tracking the Progression and Influence of Beta-Amyloid Plaques Using Percolation Centrality and Collective Influence Algorithm: A Study Using PET Images.

ABSTRACT:

Background

The study of brain networks, particularly the spread of disease, is made easier thanks to the network theory. The aberrant accumulation of beta-amyloid plaques and tau protein tangles in Alzheimer's disease causes disruption in brain networks. The evaluation scores, such as the mini-mental state examination (MMSE) and neuropsychiatric inventory questionnaire, which provide a clinical diagnosis, are affected by this build-up.

Purpose

The percolation of beta-amyloid/tau tangles and their impact on cognitive tests are still unspecified.

Methods

Percolation centrality could be used to investigate beta-amyloid migration as a characteristic of positron emission tomography (PET)-image-based networks. The PET-image-based network was built utilizing a public databas

SUBMITTER: Baboo GK 

PROVIDER: S-EPMC10101156 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature