Clinical characterization and genomic landscape of gynecological cancers among patients attending a Chinese hospital.

ABSTRACT:

Background

Gynecological cancers are the most lethal malignancies among females, most of which are associated with gene mutations. Few studies have compared the differences in the genomic landscape among various types of gynecological cancers. In this study, we evaluated the diversity of mutations in different gynecological cancers.

Methods

A total of 184 patients with gynecological cancer, including ovarian, cervical, fallopian tube, and endometrial cancer, were included. Next-generation sequencing was performed to detect the mutations and tumor mutational burden (TMB). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses were also conducted.

Results

We found that 94.57% of patients had at least one mutation, among which single nu

SUBMITTER: Jiang C 

PROVIDER: S-EPMC10101327 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature