Breakthrough infections due to SARS-CoV-2 Delta variant: relation to humoral and cellular vaccine responses.

ABSTRACT:

Introduction

COVID-19 vaccines are expected to provide effective protection. However, emerging strains can cause breakthrough infection in vaccinated individuals. The immune response of vaccinated individuals who have experienced breakthrough infection is still poorly understood.

Methods

Here, we studied the humoral and cellular immune responses of fully vaccinated individuals who subsequently experienced breakthrough infection due to the Delta variant of SARS-CoV-2 and correlated them with the severity of the disease.

Results

In this study, an effective humoral response alone was not sufficient to induce effective immune protection against severe breakthrough infection, which also required effective cell-mediated immunity to SARS-CoV-2. Patients who did not require o

SUBMITTER: Buscot M 

PROVIDER: S-EPMC10101330 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature