Multi-omic insights into Parkinson's Disease: From genetic associations to functional mechanisms.

ABSTRACT: Genome-Wide Association Studies (GWAS) have elucidated the genetic components of Parkinson's Disease (PD). However, because the vast majority of GWAS association signals fall within non-coding regions, translating these results into an interpretable, mechanistic understanding of the disease etiology remains a major challenge in the field. In this review, we provide an overview of the approaches to prioritize putative causal variants and genes as well as summarise the primary findings of previous studies. We then discuss recent efforts to integrate multi-omics data to identify likely pathogenic cell types and biological pathways implicated in PD pathogenesis. We have compiled full summary statistics of cell-type, tissue, and phentoype enrichment analyses from multiple studies of PD GWAS and

SUBMITTER: Schilder BM 

PROVIDER: S-EPMC10101343 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature