Molecular characterization of BK virus detected in renal transplant patients in Sri Lanka: a preliminary study.

ABSTRACT:

Background & objectives

BK virus (BKV) is a polyomavirus and cause of a common infection after renal transplantation which could be preceded to BKV-associated nephropathy. It has four main subtypes (I-IV). BKV subtypes II and III are rare, whereas subtype I shows a ubiquitous distribution. The objective of the present study was to investigate the prevailing BKV subtypes and subgroups in renal transplant patients in Sri Lanka.

Methods

The presence of BKV in urine was tested through virus load quantification by real-time PCR from 227 renal transplant patients who were suspected to have BKV infection. Of these patients only 41 were found to be BKV infected (>10³ copies/ml) and those were subjected to conventional PCR amplification of VP1 gene followed by BKV genotypi

SUBMITTER: Yashodha Ratnayake AKDV 

PROVIDER: S-EPMC10101357 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature