Risk factors associated with the discordance in kidney function decline rate in identical twins.

ABSTRACT:

Background

The rate of kidney function decline is different for each individual regardless of any difference in the medical histories. This study set out to identify the risk factors for high discordance in kidney function decline in an identical twin cohort.

Methods

This study included 333 identical twins from the Korean Genome and Epidemiology Study who were categorized into two groups according to the estimated glomerular filtration rate (eGFR) decline: the slow and rapid progressor groups. The mean differences of variables were compared between the two groups. We calculated the difference in the annual eGFR change between twins and analyzed the risk factors associated with high discordance in twins who had > 5 mL/min/1.73 m2 /yr of the intra-twin difference in the annual

SUBMITTER: Hwang JA 

PROVIDER: S-EPMC10101412 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature