Predicting late-stage age-related macular degeneration by integrating marginally weak SNPs in GWA studies.

ABSTRACT: Introduction: Age-related macular degeneration (AMD) is a progressive neurodegenerative disease and the leading cause of blindness in developed countries. Current genome-wide association studies (GWAS) for late-stage age-related macular degeneration are mainly single-marker-based approaches, which investigate one Single-Nucleotide Polymorphism (SNP) at a time and postpone the integration of inter-marker Linkage-disequilibrium (LD) information in the downstream fine mappings. Recent studies showed that directly incorporating inter-marker connection/correlation into variants detection can help discover novel marginally weak single-nucleotide polymorphisms, which are often missed in conventional genome-wide association studies, and can also help improve disease prediction accuracy.

SUBMITTER: Zhou X 

PROVIDER: S-EPMC10101437 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature