Detection of persistent low IgG avidity-an interpretative problem in the diagnosis of acute toxoplasmosis.

ABSTRACT:

Objectives

For the proper diagnosis of toxoplasmosis it is essential to determine the stage of the infection, for which the most preferred method is IgG avidity test. The avidity index (AI) should initially be low (AI≤0.3) in the acute phase and increase during the infection. However, persistent low avidity can occur in patients with latent toxoplasmosis, which can complicate the interpretation of the results. The aim of the study is to explain the causes of this phenomenon.

Methodology

A retrospective study was carried out with 717 serum samples collected from 442 patients from the categories of pregnant and non-pregnant women, men, and newborns + infants (age < 0.5 year). The trends of AI kinetics were evaluated in repeatedly examined patients. The frequency of cases with

SUBMITTER: Kodym P 

PROVIDER: S-EPMC10101438 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature