Sequential bilateral accelerated theta burst stimulation in adolescents with suicidal ideation associated with major depressive disorder: Protocol for a randomized controlled trial.

ABSTRACT:

Background

Suicide is a leading cause of death in adolescents worldwide. Previous research findings suggest that suicidal adolescents with depression have pathophysiological dorsolateral prefrontal cortex (DLPFC) deficits in γ-aminobutyric acid neurotransmission. Interventions with transcranial magnetic stimulation (TMS) directly address these underlying pathophysiological deficits in the prefrontal cortex. Theta burst stimulation (TBS) is newer dosing approach for TMS. Accelerated TBS (aTBS) involves administering multiple sessions of TMS daily as this dosing may be more efficient, tolerable, and rapid acting than standard TMS.

Materials and methods

This is a randomized, double-blind, sham-controlled trial of sequential bilateral aTBS in adolescents with major depressive di

SUBMITTER: Yuruk D 

PROVIDER: S-EPMC10101506 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature