Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans wild strains.

ABSTRACT: Treatment of parasitic nematode infections in humans and livestock relies on a limited arsenal of anthelmintic drugs that have historically reduced parasite burdens. However, anthelmintic resistance (AR) is increasing, and little is known about the molecular and genetic causes of resistance for most drugs. The free-living roundworm Caenorhabditis elegans has proven to be a tractable model to understand AR, where studies have led to the identification of molecular targets of all major anthelmintic drug classes. Here, we used genetically diverse C. elegans strains to perform dose-response analyses across 26 anthelmintic drugs that represent the three major anthelmintic drug classes (benzimidazoles, macrocyclic lactones, and nicotinic acetylcholine receptor agonists) in addition to seven othe

SUBMITTER: Shaver AO 

PROVIDER: S-EPMC10101645 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature