Profiles of oral microbiome associated with nasogastric tube feeding.

ABSTRACT:

Background

Dysbiosis of oral microbiome causes chronic diseases including dental caries and periodontitis, which frequently affect older patient populations. Severely disabled individuals with impaired swallowing functions may require nutritional supply via nasogastric (NG) tubes, further impacting their oral condition and possibly microbial composition. However, little is known about the effect of NG tube on oral microbes and its potential ramification.

Methods

By using 16S rRNA amplicon sequencing, we characterized the tongue microbiome of 27 patients fed with NG tubes and 26 others fed orally.

Results

The microbial compositions of NG-tube and oral-feeding patients were substantially different, with more Gram-negative aerobes enriched in the presence of NG tube. Spe

SUBMITTER: Wang DH 

PROVIDER: S-EPMC10101675 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature