In vivo effect of mouthwashes on viable viral load of SARS-CoV-2 in saliva: a pilot study.

ABSTRACT: Current data on the efficacy of antiseptic mouthwashes to reduce viral load are contradictory. Firstly, in vitro data indicate very strong virucidal effects that are not replicated in clinical studies. Secondly, most clinical studies identify a limited effect, do not include a control/placebo group, or do not evaluate viral viability in an infection model. In the current manuscript, we perform a double-blind, randomized clinical trial where salivary viral load was measured before and after the mouthwash, and where saliva samples were also cultured in an in vitro infection model of SARS-CoV-2 to evaluate the effect of mouthwashes on viral viability. Our data show a 90-99% reduction in SARS-CoV-2 salivary copies with one of the tested mouthwashes, although we show that the rema

SUBMITTER: Sanchez Barrueco A 

PROVIDER: S-EPMC10101681 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature