Impact of proactive and reactive vaccination strategies for health-care workers against MERS-CoV: a mathematical modelling study.

ABSTRACT:

Background

Several vaccine candidates are in development against MERS-CoV, which remains a major public health concern. In anticipation of available MERS-CoV vaccines, we examine strategies for their optimal deployment among health-care workers.

Methods

Using data from the 2013-14 Saudi Arabia epidemic, we use a counterfactual analysis on inferred transmission trees (who-infected-whom analysis) to assess the potential impact of vaccination campaigns targeting health-care workers, as quantified by the proportion of cases or deaths averted. We investigate the conditions under which proactive campaigns (ie vaccinating in anticipation of the next outbreak) would outperform reactive campaigns (ie vaccinating in response to an unfolding outbreak), considering vaccine efficacy, dur

SUBMITTER: Laydon DJ 

PROVIDER: S-EPMC10101755 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature