Real World Characteristics and Clinical Outcomes of HER2-Mutant Non-Small Cell Lung Cancer Patients Detected by Next-Generation Sequencing.

ABSTRACT:

Purpose

This study was conducted to investigate the clinical characteristics of patients with advanced non-small cell lung cancer (NSCLC) harboring human epidermal growth factor receptor 2 (HER2) mutations and to evaluate response to standard treatment and HER2-targeted agents.

Materials and methods

Using tissue and/or blood next-generation sequencing, we identified 44 patients with NSCLC harboring HER2 mutations who were treated at Severance Hospital between December 2016 and February 2021. Clinical data, including patient characteristics, mutation status, incidence of metastasis for distant lesions, and response to chemotherapy, were retrospectively analyzed.

Results

The median age was 58 years, and 61% of the patients were female. Most patients (64%) were never-smo

SUBMITTER: Ahn BC 

PROVIDER: S-EPMC10101791 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature