U-shaped association between serum IGF2BP3 and T2DM: A cross-sectional study in Chinese population.

ABSTRACT:

Objective

To clarify the expression of N6-methyladenosine (m⁶ A) modulators involved in the pathogenesis of type 2 diabetes mellitus (T2DM). We further explored the association of serum insulin-like growth factor 2 mRNA-binding proteins 3 (IGF2BP3) levels and odds of T2DM in a high-risk population.

Methods

The gene expression data set GSE25724 was obtained from the Gene Expression Omnibus, and a cluster heatmap was generated by using the R package ComplexHeatmap. Differential expression analysis for 13 m⁶ A RNA methylation regulators between nondiabetic controls and T2DM subjects was performed using an unpaired t test. A cross-sectional design, including 393 subjects (131 patients with newly diagnosed T2DM, 131 age- and sex-matched subjects with prediab

SUBMITTER: Wu X 

PROVIDER: S-EPMC10101838 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature