Genetic effects on the timing of parturition and links to fetal birth weight.
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ABSTRACT:
SUBMITTER: Sole-Navais P
PROVIDER: S-EPMC10101852 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
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Genetic effects on the timing of parturition and links to fetal birth weight.
Solé-Navais Pol P Flatley Christopher C Steinthorsdottir Valgerdur V Vaudel Marc M Juodakis Julius J Chen Jing J Laisk Triin T LaBella Abigail L AL Westergaard David D Bacelis Jonas J Brumpton Ben B Skotte Line L Borges Maria C MC Helgeland Øyvind Ø Mahajan Anubha A Wielscher Matthias M Lin Frederick F Briggs Catherine C Wang Carol A CA Moen Gunn-Helen GH Beaumont Robin N RN Bradfield Jonathan P JP Abraham Abin A Thorleifsson Gudmar G Gabrielsen Maiken E ME Ostrowski Sisse R SR Modzelewska Dominika D Nohr Ellen A EA Hypponen Elina E Srivastava Amit A Talbot Octavious O Allard Catherine C Williams Scott M SM Menon Ramkumar R Shields Beverley M BM Sveinbjornsson Gardar G Xu Huan H Melbye Mads M Lowe William W Bouchard Luigi L Oken Emily E Pedersen Ole B OB Gudbjartsson Daniel F DF Erikstrup Christian C Sørensen Erik E Lie Rolv T RT Teramo Kari K Hallman Mikko M Juliusdottir Thorhildur T Hakonarson Hakon H Ullum Henrik H Hattersley Andrew T AT Sletner Line L Merialdi Mario M Rifas-Shiman Sheryl L SL Steingrimsdottir Thora T Scholtens Denise D Power Christine C West Jane J Nyegaard Mette M Capra John A JA Skogholt Anne H AH Magnus Per P Andreassen Ole A OA Thorsteinsdottir Unnur U Grant Struan F A SFA Qvigstad Elisabeth E Pennell Craig E CE Hivert Marie-France MF Hayes Geoffrey M GM Jarvelin Marjo-Riitta MR McCarthy Mark I MI Lawlor Deborah A DA Nielsen Henriette S HS Mägi Reedik R Rokas Antonis A Hveem Kristian K Stefansson Kari K Feenstra Bjarke B Njolstad Pål P Muglia Louis J LJ Freathy Rachel M RM Johansson Stefan S Zhang Ge G Jacobsson Bo B
Nature genetics 20230403 4
The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration. Analy ...[more]
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