Gene expression profile analyses to identify potential biomarkers for myopia.

ABSTRACT:

Purpose

Increasing evidence suggests myopia is not a simple refractive error, many other factors might also be involved. Here, we assessed myopic and normal corneas' gene expression profiles to identify possible diagnostic and therapeutic biomarkers for myopia.

Materials and methods

We obtained the expression profile of ten patients and seven normal control samples from the GSE112155 and GSE151631 datasets based on the Gene Expression Omnibus (GEO) database. We used the "limma" R package to determine the differentially expressed genes (DEGs) between myopic and normal corneas. Weighted gene co-expression network analysis (WGCNA) was used to identify critical co-expressed modules related to myopia, and enrichment analyses were used to annotate the function of genes encompassed

SUBMITTER: Ni Y 

PROVIDER: S-EPMC10101995 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature