Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia.

ABSTRACT: Studies of primary visual cortex have furthered our understanding of amblyopia, long-lasting visual impairment caused by imbalanced input from the two eyes during childhood, which is commonly treated by patching the dominant eye. However, the relative impacts of monocular vs. binocular visual experiences on recovery from amblyopia are unclear. Moreover, while sleep promotes visual cortex plasticity following loss of input from one eye, its role in recovering binocular visual function is unknown. Using monocular deprivation in juvenile male mice to model amblyopia, we compared recovery of cortical neurons' visual responses after identical-duration, identical-quality binocular or monocular visual experiences. We demonstrate that binocular experience is quantitatively superior in restoring bi

SUBMITTER: Martinez JD 

PROVIDER: S-EPMC10102075 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature