Alterations of CD8⁺ T cells in the blood and salivary glands of patients with primary Sjogren's syndrome.

ABSTRACT:

Objective

To identify the alterations of CD8⁺ T cells in blood and labial salivary glands (LSGs) of patients with Primary Sjögren's syndrome (pSS).

Methods

Blood samples from 24 pSS patients were assayed for CD38⁺ HLA-DR⁺ CD8⁺ (activated CD8⁺, aCD8⁺) T cells and serum IFN-γ and TNF-α, using flow cytometry and ELISA respectively, and compared with samples from 27 healthy controls. Immunohistochemistry was used to count CD8⁺ T cells in LSG tissues of 24 pSS patients and of 6 control patients with normal pathology.

Results

pSS patients had more aCD8⁺ T cells than aCD4⁺ T cells (medians 33.13% vs. 9.43%, p < 0.0001), and had an increased level of aCD8⁺ T cells (me

SUBMITTER: Li H 

PROVIDER: S-EPMC10102090 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature