Ancestral and environmental patterns in the association between triglycerides and other cardiometabolic risk factors.

ABSTRACT:

Background

West Africans and African Americans with substantial (∼80%) West African ancestry are characterized by low levels of triglycerides (TG) compared to East Africans and Europeans. The impact of these varying TG levels on other cardiometabolic risk factors is unclear. We compared the strength of association between TG with hypertension, blood pressure, BMI, waist circumference, type 2 diabetes (T2D), and fasting glucose across West African (WA), East African (EA), and European (EU) ancestry populations residing in three vastly different environmental settings: sub-Saharan Africa, United States, and Europe.

Methods

We analysed data from four cross-sectional studies that included WA in sub-Saharan Africa (n = 7201), the U.S. (n = 4390), and Europe (n = 6436), EA in sub-

SUBMITTER: Meeks KAC 

PROVIDER: S-EPMC10102222 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature