Effect of endoscopic sleeve gastroplasty on gastric emptying, motility and hormones: a comparative prospective study.

ABSTRACT:

Objective

Endoscopic sleeve gastroplasty (ESG) has gained global adoption but our understanding of its mechanism(s) of action and durability of efficacy is limited. We sought to determine changes in gastric emptying (GE), gastric motility (GM), hormones and eating behaviours after ESG.

Design

A priori-designed single-centre substudy of a large US randomised clinical trial, adults with obesity were randomised to ESG or lifestyle interventions (LS) alone. We measured GE, hormones and weight loss and assessed eating behaviours. In a subset of ESG patients, we assessed GM. The primary outcome was the change in T_1/2 (min) at 3 months, and secondary outcomes were changes in weight, GE, GM, hormones and eating behaviours. We used t-test analyses and regression to

SUBMITTER: Vargas EJ 

PROVIDER: S-EPMC10102256 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature