Obesity, but not high-fat diet, is associated with bone loss that is reversed via CD4⁺CD25⁺Foxp3⁺ Tregs-mediated gut microbiome of non-obese mice.

ABSTRACT: Osteoporosis is characterized by decreased bone mass, microarchitectural deterioration, and increased bone fragility. High-fat diet (HFD)-induced obesity also results in bone loss, which is associated with an imbalanced gut microbiome. However, whether HFD-induced obesity or HFD itself promotes osteoclastogenesis and consequent bone loss remains unclear. In this study, we developed HFD-induced obesity (HIO) and non-obesity (NO) mouse models to evaluate the effect of HFD on bone loss. NO mice were defined as body weight within 5% of higher or lower than that of chow diet fed mice after 10 weeks HFD feeding. NO was protected from HIO-induced bone loss by the RANKL /OPG system, with associated increases in the tibia tenacity, cortical bone mean density, bone volume of cancellous bone, and tra

SUBMITTER: Song W 

PROVIDER: S-EPMC10102288 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature