Identifying TNF and IL6 as potential hub genes and targeted drugs associated with scleritis: A bio-informative report.

ABSTRACT:

Background

Scleritis is a serious inflammatory eye disease that can lead to blindness. The etiology and pathogenesis of scleritis remain unclear, and increasing evidence indicates that some specific genes and proteins are involved. This study aimed to identify pivotal genes and drug targets for scleritis, thus providing new directions for the treatment of this disease.

Methods

We screened candidate genes and proteins associated with scleritis by text-mining the PubMed database using Python, and assessed their functions by using the DAVID database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used to identify the functional enrichment of these genes and proteins. Then, the hub genes were identified with CytoHubba and assessed by protein-

SUBMITTER: Yan F 

PROVIDER: S-EPMC10102337 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature