DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke.

ABSTRACT:

Purpose

Brain glymphatic dysfunction is involved in the pathologic process of acute ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in subacute IS has not been fully elucidated. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was used in this study to explore whether glymphatic activity was related to motor dysfunction in subacute IS patients.

Methods

Twenty-six subacute IS patients with a single lesion in the left subcortical region and 32 healthy controls (HCs) were recruited in this study. The DTI-ALPS index and DTI metrics (fractional anisotropy, FA, and mean diffusivity, MD) were compared within and between groups. Spearman's and Pearson's partial correlation analyses were performed to analyze the re

SUBMITTER: Qin Y 

PROVIDER: S-EPMC10102345 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature