Proteomic analysis of metronidazole resistance in the human facultative pathogen Bacteroides fragilis.

ABSTRACT: The anaerobic gut bacteria and opportunistic pathogen Bacteroides fragilis can cause life-threatening infections when leaving its niche and reaching body sites outside of the gut. The antimicrobial metronidazole is a mainstay in the treatment of anaerobic infections and also highly effective against Bacteroides spp. Although resistance rates have remained low in general, metronidazole resistance does occur in B. fragilis and can favor fatal disease outcomes. Most metronidazole-resistant Bacteroides isolates harbor nim genes, commonly believed to encode for nitroreductases which deactivate metronidazole. Recent research, however, suggests that the mode of resistance mediated by Nim proteins might be more complex than anticipated because they affect

SUBMITTER: Paunkov A 

PROVIDER: S-EPMC10102347 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature