Comprehensive analysis of prognosis of cuproptosis-related oxidative stress genes in multiple myeloma.

ABSTRACT: Introduction: Multiple myeloma (MM) is a highly heterogeneous hematologic malignancy. The patients' survival outcomes vary widely. Establishing a more accurate prognostic model is necessary to improve prognostic precision and guide clinical therapy. Methods: We developed an eight-gene model to assess the prognostic outcome of MM patients. Univariate Cox analysis, Least absolute shrinkage and selection operator (LASSO) regression, and multivariate Cox regression analyses were used to identify the significant genes and construct the model. Other independent databases were used to validate the model. Results: The results showed that the overall survival of patients in the high-risk group was signifificantly shorter compared with that of those in the low-risk group. The ei

SUBMITTER: Li T 

PROVIDER: S-EPMC10102368 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature