Deep characterization of human γδ T cell subsets defines shared and lineage-specific traits.

ABSTRACT: Under non-pathological conditions, human γδ T cells represent a small fraction of CD3⁺ T cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that recognize stress ligands or non-peptide antigens through MHC-independent presentation. Major human γδ T cell subsets, Vδ1 and Vδ2, expand in response to microbial infection or malignancy, but possess distinct tissue localization, antigen recognition, and effector responses. We hypothesized that differences at the gene, phenotypic, and functional level would provide evidence that γδ T cell subpopulations belong to distinct lineages. Comparisons between each subset and the identification of the molecular determinants that underpin their differences has been hampered by experimental challenges in obtaining

SUBMITTER: Sanz M 

PROVIDER: S-EPMC10102470 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature