Construction and validation of a metabolic-associated lncRNA risk index for predicting colorectal cancer prognosis.

ABSTRACT:

Background

Metabolic reprogramming is one of the most important events in the development of tumors. Similarly, long non-coding RNAs are closely related to the occurrence and development of colorectal cancer (CRC). However, there is still a lack of systematic research on metabolism-related lncRNA in CRC.

Methods

Expression data of metabolism-related genes and lncRNA were obtained from The Cancer Genome Atlas (TCGA). Hub metabolism-related genes (HMRG) were screened out by differential analysis and univariate Cox analysis; a metabolism-related lncRNA risk index (MRLncRI) was constructed by co-expression analysis, univariate Cox regression analysis, LASSO, and multivariate Cox regression analysis. Survival curves were drawn by the Kaplan-Meier method. The ssGSEA method assesse

SUBMITTER: Lin Q 

PROVIDER: S-EPMC10102509 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature