Spatial patterns of elevated magnetic susceptibility in progressive apraxia of speech.

ABSTRACT:

Purpose

Progressive apraxia of speech (PAOS) is a neurodegenerative disorder affecting the planning or programming of speech. Little is known about its magnetic susceptibility profiles indicative of biological processes such as iron deposition and demyelination. This study aims to clarify (1) the pattern of susceptibility in PAOS patients, (2) the susceptibility differences between the phonetic (characterized by predominance of distorted sound substitutions and additions) and prosodic (characterized by predominance of slow speech rate and segmentation) subtypes of PAOS, and (3) the relationships between susceptibility and symptom severity.

Methods

Twenty patients with PAOS (nine phonetic and eleven prosodic subtypes) were prospectively recruited and underwent a 3 Tesla MRI s

SUBMITTER: Satoh R 

PROVIDER: S-EPMC10102559 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature