Silent infarction in sickle cell disease is associated with brain volume loss in excess of infarct volume.

ABSTRACT:

Introduction

Sickle cell disease (SCD) increases cerebral infarct risk, but reported effects on brain volume have varied. More detailed information using larger cohorts and contemporary methods could motivate the use of longitudinal brain volume assessment in SCD as an automated marker of disease stability or future progression. The purpose of this study was to rigorously evaluate whether children and young adults with SCD have reduced gray matter volume (GMV) and white matter volume (WMV) compared to healthy controls using high-resolution MRI. We tested the hypotheses that (i) elevated CBF, a marker of cerebral hemodynamic compensation in SCD, is associated with global and regional brain atrophy, and (ii) silent cerebral infarct burden is associated with brain atrophy in excess of

SUBMITTER: Jones RS 

PROVIDER: S-EPMC10102616 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature