Afro-TB dataset as a large scale genomic data of Mycobacterium tuberuclosis in Africa.

ABSTRACT: Mycobacterium tuberculosis (MTB) is a pathogenic bacterium accountable for 10.6 million new infections with tuberculosis (TB) in 2021. The fact that the genetic sequences of M. tuberculosis vary widely provides a basis for understanding how this bacterium causes disease, how the immune system responds to it, how it has evolved over time, and how it is distributed geographically. However, despite extensive research efforts, the evolution and transmission of MTB in Africa remain poorly understood. In this study, we used 17,641 strains from 26 countries to create the first curated African Mycobacterium tuberculosis (MTB) classification and resistance dataset, containing 13,753 strains. We identified 157 mutations in 12 genes associated with resistance and additional new mutations potentially

SUBMITTER: Laamarti M 

PROVIDER: S-EPMC10102689 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature