Cortical connectivity of cholinergic basal forebrain in Parkinson's disease with mild cognitive impairment.

ABSTRACT:

Background

Cholinergic basal forebrain (BF) pathology is a hallmark of Parkinson's disease (PD) with mild cognitive impairment (PD-MCI). Assessment of functional connectivity (FC) of different cholinergic BF nuclei may deepen the understanding of PD-MCI pathogenesis.

Methods

Seed-based FC analysis was performed with bilateral medial septal nucleus, the nucleus of the vertical limb of the diagonal band, nucleus of the horizontal limb of the diagonal band (Ch1-3), and the nucleus basalis of Meynert (NBM/Ch4) to explore the BF functional alterations in different frequency bands. Correlations between FC values of abnormal regions and scores of cognitive domains and depression in the PD group were also assessed.

Results

For the right Ch4, in the conventional frequency band

SUBMITTER: Zhang P 

PROVIDER: S-EPMC10102747 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature