Renal ischemia-reperfusion injury in rabbits evaluated with quantitative susceptibility mapping: an animal study.

ABSTRACT:

Background

There were no effective noninvasive methods to diagnose renal ischemia-reperfusion injury (IRI), which is a major clinical problem. The objective of this study was to explore the feasibility of the quantitative susceptibility mapping (QSM) technique in evaluating the dynamic changes in the renal IRI process.

Methods

A total of 36 New Zealand rabbits were randomly assigned to the IRI group (n=30) and the sham group (n=6). All rabbits underwent magnetic resonance imaging (MRI) examination, including T2-weighted imaging and QSM before the operation (pre-IRI) and 1, 12, 24, and 48 h after the operation (IRI-1h, IRI-12h, IRI-24h, and IRI-48h, respectively). Regions of interest were manually delineated in the outer medulla. All specimens were stained with hematoxylin an

SUBMITTER: Luo K 

PROVIDER: S-EPMC10102784 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature