MR elastography identifies regions of extracellular matrix reorganization associated with shorter survival in glioblastoma patients.

ABSTRACT:

Background

Biomechanical tissue properties of glioblastoma tumors are heterogeneous, but the molecular mechanisms involved and the biological implications are poorly understood. Here, we combine magnetic resonance elastography (MRE) measurement of tissue stiffness with RNA sequencing of tissue biopsies to explore the molecular characteristics of the stiffness signal.

Methods

MRE was performed preoperatively in 13 patients with glioblastoma. Navigated biopsies were harvested during surgery and classified as "stiff" or "soft" according to MRE stiffness measurements (|G*|_norm). Twenty-two biopsies from eight patients were analyzed by RNA sequencing.

Results

The mean whole-tumor stiffness was lower than normal-appearing white matter. The surgeon's stiffness eva

SUBMITTER: Svensson SF 

PROVIDER: S-EPMC10102831 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature