Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy.

ABSTRACT: The inflammatory microenvironment of solid tumors creates a protumorigenic milieu that resembles chronic inflammation akin to a subverted wound healing response. Here, we investigated the effect of converting the tumor microenvironment from a chronically inflamed state to one of acute microbial inflammation by injecting microbial bioparticles directly into tumors. Intratumoral microbial bioparticle injection led to rapid and dramatic changes in the tumor immune composition, the most striking of which was a substantial increase in the presence of activated neutrophils. In situ photoconversion and intravital microscopy indicated that tumor neutrophils transiently switched from sessile producers of VEGF to highly motile neutrophils that clustered to make neutrophil-rich domains in the tumor.

SUBMITTER: Yam AO 

PROVIDER: S-EPMC10102850 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature