G-Quadruplex Structures Are Key Modulators of Somatic Structural Variants in Cancers.

ABSTRACT: G-quadruplexes (G4) are noncanonical secondary genome structures. Aberrant formation of G4s can impair genome integrity. Investigation of the relationship between G4s and somatic structural variants (SV) in cancers could provide a better understanding of the role of G4 formation in cancer development and progression. In this study, we combined bioinformatic approaches and multiomics data to investigate the connection between G4s and the somatic SVs. Somatic SV breakpoints were significantly enriched in G4 regions, regardless of SV subtypes. This enrichment was only observed in regions demonstrated to form G4s in cells ("active quadruplexes"), rather than in regions with a sequence compatible with G4 formation but without confirmed G4 formation ("potential quadruplexes"). Several genomic fe

SUBMITTER: Zhang R 

PROVIDER: S-EPMC10102852 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature