Acquired Esophageal Strictures in Children: Morphometric and Immunohistochemical Analyses.

ABSTRACT:

Background

Esophageal strictures (ES) in children are not well characterized pathologically. We report unique histopathologic analyses of resected acquired ES and control esophagi (CE).

Methods

Muscle layer thicknesses were measured in intact well-oriented areas; inflammatory cells were counted in the most inflamed high power field (hpf). Sections were stained with relevant antibodies. Results were expressed as median, lower and upper quartiles. Wilcoxon Rank Sums non-parametric test was used to compare groups; P ≤ 0.05 was considered significant.

Results

All ES (N = 10) showed focal replacement of lamina propria, muscularis mucosa and submucosa by actin+ fibers emanating from muscularis propria. Compared to CE (N = 8), ES displayed significantly thickened musc

SUBMITTER: Collins MH 

PROVIDER: S-EPMC10102868 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature