Molecular analysis of duodenal eosinophilia.

ABSTRACT:

Background

Eosinophilic duodenitis (EoD), characterized by nonspecific gastrointestinal symptoms and increased numbers of duodenal eosinophils, may be in the eosinophilic gastrointestinal disease spectrum. However, diagnostic thresholds and pathogenic processes of duodenal tissue eosinophilia are inadequately characterized.

Objective

We aimed to define an EoD transcriptome and pathologic pathways.

Methods

RNA sequencing and histologic features of human duodenal biopsy samples were analyzed as a function of duodenal eosinophils levels. For analyses, we defined EoD as more than 52 peak eosinophils/hpf (n = 8), duodenal eosinophilia as 30 to 52 eosinophils/hpf (n = 11), and normal controls as fewer than 30 eosinophils/hpf (n = 8). Associations between gene expression and

SUBMITTER: Shoda T 

PROVIDER: S-EPMC10102870 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature