Clinical, immunological, and microbiological analysis of the association between periodontitis and COVID-19: a case-control study.

ABSTRACT:

Purpose

Periodontitis and coronavirus disease (COVID-19) share risk factors and activate similar immunopathological pathways, intensifying systemic inflammation. This study investigated the clinical, immunological and microbiological parameters in individuals with COVID-19 and controls, exploring whether periodontitis-driven inflammation contributes to worsening COVID-19 endpoints.

Methods

Case (positive RT-PCR for SARS-CoV-2) and control (negative RT-PCR) individuals underwent clinical and periodontal assessments. Salivary levels of TNF-α, IL-6, IL-1β, IL-10, OPG, RANKL, neutrophil extracellular traps, and subgingival biofilm were analyzed at two timepoints. Data on COVID-19-related outcomes and comorbidity information were evaluated from medical records.

Results

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SUBMITTER: Bemquerer LM 

PROVIDER: S-EPMC10103045 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature