Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors.

ABSTRACT:

Background and objectives

Blood pressure (BP) is often not at goal in stroke survivors, leaving individuals vulnerable to additional vascular events. Given that BP is a highly heritable trait, we hypothesize that a higher polygenic susceptibility to hypertension (PSH) leads to worse BP control in stroke survivors.

Methods

We conducted a study within the UK Biobank evaluating persons of European ancestry who survived an ischemic or hemorrhagic stroke. To model the PSH, we created polygenic risk scores (PRSs) for systolic and diastolic BP using 732 genetic variants. We divided the PRSs into quintiles and used linear/logistic regression to test whether higher PSH led to higher observed BP, uncontrolled BP (systolic BP > 140 mm Hg or diastolic BP > 90 mm Hg), and resistant BP (u

SUBMITTER: Acosta JN 

PROVIDER: S-EPMC10103110 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature