Risk Stratification to Predict Renal Survival in Anti-Glomerular Basement Membrane Disease.

ABSTRACT:

Significance statement

Most patients with anti-glomerular basement membrane (GBM) disease present with rapidly progressive glomerulonephritis, and more than half develop ESKD. Currently, no tools are available to aid in the prognostication or management of this rare disease. In one of the largest assembled cohorts of patients with anti-GBM disease (with 174 patients included in the final analysis), the authors demonstrated that the renal risk score for ANCA-associated vasculitis is transferable to anti-GBM disease and the renal histology is strongly predictive of renal survival and recovery. Stratifying patients according to the percentage of normal glomeruli in the kidney biopsy and the need for RRT at the time of diagnosis improves outcome prediction. Such stratification may assi

SUBMITTER: Floyd L 

PROVIDER: S-EPMC10103284 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature