Health Care Resource Utilization and Costs of Persistent Severe Acute Kidney Injury (PS-AKI) Among Hospitalized Stage 2/3 AKI Patients.
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ABSTRACT:
SUBMITTER: Koyner JL
PROVIDER: S-EPMC10103312 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
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Health Care Resource Utilization and Costs of Persistent Severe Acute Kidney Injury (PS-AKI) Among Hospitalized Stage 2/3 AKI Patients.
Koyner Jay L JL Mackey Rachel H RH Rosenthal Ning A NA Carabuena Leslie A LA Kampf J Patrick JP Echeverri Jorge J McPherson Paul P Blackowicz Michael J MJ Rodriguez Toni T Sanghani Aarti R AR Textoris Julien J
Kidney360 20230301 3
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Project description:A real-world US database analysis was conducted to evaluate the hospital resource utilization and costs of patients hospitalized for venous thromboembolism (VTE) treated with warfarin versus apixaban. Additionally, 1-month readmissions were evaluated. Of 28 612 patients with VTE identified from the Premier Hospital database (August 2014-May 2016), 91% (N = 26 088) received warfarin and 9% (N = 2524) received apixaban. Outcomes were assessed after controlling for key patient/hospital characteristics. For index hospitalizations, the average length of stay (LOS) was longer (3.8 vs 3.1 days, P < .001; difference: 0.7 days) and mean hospitalization cost higher (US$3224 vs US$2,740, P < .001; difference: US$484) for warfarin versus apixaban-treated patients. During the 1-month follow-up period, warfarin treatment was associated with a greater risk of all-cause readmission (odds ratio [OR]: 1.27; 95% confidence interval [CI]: 1.09-1.48, P = .003), major bleeding (MB)-related readmission (OR: 2.10; 95% CI: 1.03-4.27, P = .04), and any bleeding-related readmission (OR: 1.67; 95% CI: 1.09-2.56, P = .02) versus apixaban. The results of this real-world analysis show that compared to warfarin, apixaban treatment was associated with shorter index hospital stays, lower index hospitalization costs, and reduced risk of MB-related readmissions among hospitalized patients with VTE.
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Project description:ObjectivesAcute kidney injury (AKI) is a sudden episode of kidney failure or damage and the risk of AKI is determined by the complex interactions of patient factors. In this study, we aimed to find out which risk factors in hospitalized patients are more likely to indicate severe AKI.MethodsWe constructed a retrospective cohort of adult patients from all inpatient units of a tertiary care academic hospital between November 2007 and December 2016. AKI predictors included demographic information, admission and discharge dates, medications, laboratory values, past medical diagnoses and admission diagnosis. We developed a machine learning-based knowledge mining model and a screening framework to analyze which risk predictors are more likely to imply severe AKI in hospitalized populations.ResultsAmong the final analysis cohort of 76,957 hospital admissions, AKI occurred in 7,259 (9.43 %) with 6,396 (8.31 %) at stage 1, 678 (0.88 %) at stage 2, and 185 (0.24 %) at stage 3. We compared the non-AKI (without AKI) vs any AKI (stages 1-3), and mild AKI (stage 1) vs severe AKI (stages 2 and 3), where the best cross-validated area under the receiver operator characteristic curve (AUC) were 0.81 (95 % CI, 0.79-0.82) and 0.66 (95 % CI, 0.62-0.71), respectively. Using the developed knowledge mining model and screening framework, we identified 33 risk predictors indicating that severe AKI may occur.ConclusionsThis study screened out 33 risk predictors that are more likely to indicate severe AKI in hospitalized patients, which would help strengthen the early care and prevention of patients.
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Project description:BackgroundRecently, there has been an increase in the incidence of colorectal cancer in Saudi Arabia. Although numerous studies worldwide have investigated the economic burden of colorectal cancer the information specific to Saudi Arabia remains limited. While advanced cancer treatments offer substantial benefits, they they also come with substantial financial challenges.ObjectiveThis study aimed to estimate the economic burden of colorectal cancer and identify the primary cost drivers.MethodThis retrospective, single-center cost of illness study examined all patients with colorectal cancer from January 2017 to December 2020. This study used a micro-costing, bottom-up approach to estimate healthcare resource utilization and direct medical costs associated with colorectal cancer.ResultThe study included 326 patients with colorectal cancer. The total direct medical cost for all patients were $19 million, with an annual cost per patient of $58,384. Medication costs were the primary driver of healthcare spending (45%) of the total cost, followed by surgical costs (27%). This study explained cost associated with colorectal cancer, which represents a significant cost to the Saudi healthcare budget. The expected growth and aging of the population and availability of costly treatments may lead to an increase in costs. These findings are valuable for healthcare policymakers seeking to comprehend the economic challenges posed by colorectal cancer.
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Project description:PurposeWe sought to expand the currently limited, Canadian, population-based data on the characteristics, treatment pathways, and health care costs according to stage in patients with human epidermal growth factor receptor-2 positive (HER2+) breast cancer (BC).MethodsWe extracted data from the publicly funded health care system in Ontario. Baseline characteristics, treatment patterns, and health care costs were descriptively compared by cancer stage (I-III vs. IV) for adult women diagnosed with invasive HER2+ BC between 2012 and 2016. Resource use was multiplied by unit costs for publicly funded health care services to calculate costs.ResultsOverall, 4535 patients with stage I-III and 354 with stage IV HER2+ BC were identified. Most patients with stage I-III disease were treated with surgery (4372, 96.4%), with the majority having a lumpectomy, and 3521 (77.6%) received radiation. Neoadjuvant (NAT) and adjuvant (AT) systemic treatment rates were 20.1% (n = 920) and 88.8% (n = 3065), respectively. Systemic treatment was received by 311 patients (87.9%) with metastatic HER2+ BC, 264 of whom (84.9%) received trastuzumab. Annual health care costs per patient were nearly 3 times higher for stage IV vs. stage I-III HER2+ BC.ConclusionPer-patient annual costs were substantially higher for women with metastatic HER2+ BC, despite less frequent exposure to surgery and radiation compared to those with early stage disease. Increasing NAT rates in early stage disease represent a critical opportunity to prevent recurrence and reduce the costs associated with treating metastatic HER2+ BC.
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