Prevotella histicola suppresses ferroptosis to mitigate ethanol-induced gastric mucosal lesions in mice.

ABSTRACT:

Background

Ethanol-induced gastric mucosal lesions (EGML) is one of the most common digestive disorders for which current therapies have limited outcomes in clinical practice. Prevotella histicola (P. histicola) has shown probiotic efficacy against arthritis, multiple sclerosis and oestrogen deficiency-induced depression in mice; however, its role in EGML remains unclear in spite of its extensive colonisation of the stomach. Ferroptosis, which is characterised by lipid peroxidation, may be involved in EGML. Herein, we aimed to investigate the effects and underlying mechanism of action of P. histicola on EGML in the ferroptosis-dependent pathway.

Methods

P. histicola was intragastrically administered for a week, and deferoxamine (DFO), a ferroptosis inhibitor, was intraperito

SUBMITTER: Wang S 

PROVIDER: S-EPMC10103513 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature