Characterizing CFTR modulated sweat chloride response across the cf population: Initial results from the CHEC-SC study.

ABSTRACT:

Background

CHEC-SC is an ongoing epidemiologic study characterizing modulator-induced sweat chloride (SC) responses across the CF population, with interim results available prior to the availability of triple combination modulator therapy.

Methods

Eligible participants had been prescribed a modulator for ≥90 days with re-enrollment allowed upon establishment of a new modulator. Pre-modulator SC values were obtained from chart review; post-modulator sweat was collected and analyzed locally. SC changes were descriptively summarized with biologic sex effects adjusted for age, weight, and CFTR genotype. Heterogeneity in ivacaftor SC response was characterized in relation to published CFTR functional responses.

Results

1848 participants provided 2004 SC measurements, 26.2%

SUBMITTER: Mayer-Hamblett N 

PROVIDER: S-EPMC10103635 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature