RORγt-Expressing Pathogenic CD4⁺ T Cells Cause Brain Inflammation during Chronic Colitis.

ABSTRACT: Neurobehavioral disorders and brain abnormalities have been extensively reported in both Crohn's disease and ulcerative colitis patients. However, the mechanism causing neuropathological disorders in inflammatory bowel disease patients remains unknown. Studies have linked the Th17 subset of CD4⁺ T cells to brain diseases associated with neuroinflammation and cognitive impairment, including multiple sclerosis, ischemic brain injury, and Alzheimer's disease. To better understand how CD4⁺ T lymphocytes contribute to brain pathology in chronic intestinal inflammation, we investigated the development of brain inflammation in the T cell transfer model of chronic colitis. Our findings demonstrate that CD4⁺ T cells infiltrate the brain of colitic Rag1 ^-

SUBMITTER: Mickael ME 

PROVIDER: S-EPMC10103644 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature