Age-associated suppression of exploratory activity during sickness is linked to meningeal lymphatic dysfunction and microglia activation.

ABSTRACT: Peripheral inflammation triggers a transient, well-defined set of behavioral changes known as sickness behavior^1-3, but the mechanisms by which inflammatory signals originating in the periphery alter activity in the brain remain obscure. Emerging evidence has established meningeal lymphatic vasculature as an important interface between the central nervous system (CNS) and the immune system, responsible for facilitating brain solute clearance and perfusion by cerebrospinal fluid (CSF)^4,5. Here, we demonstrate that meningeal lymphatics both assist microglial activation and support the behavioral response to peripheral inflammation. Ablation of meningeal lymphatics results in a heightened behavioral response to IL-1β-induced inflammation and a dampened transcriptional an

SUBMITTER: Goldman DH 

PROVIDER: S-EPMC10103743 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature