Possible protective effect of zinc administration on renal and cognitive changes occurring in uninephrectomized adult male Wistar rats.

ABSTRACT:

New findings

What is the central question of this study? Are renal changes occurring post-nephrectomy accompanied by cognitive changes, and does early administration of zinc supplements such as ZnSO₄ to uninephrectomized rats ameliorate the renal and cognitive changes if present? What is the main finding and its importance? Uninephrectomy-induced renal changes were accompanied by species-atypical behaviour in rats in both Morris water maze and T maze tests, together with hypozincaemia and hippocampal inflammatory and oxidative changes. Early zinc administration to uninephrectomized rats ameliorated the renal, behavioural, hippocampal and serum zinc changes.

Abstract

Cognitive impairment is increasingly recognized as an important consequence of kidney disease in hu

SUBMITTER: Basta M 

PROVIDER: S-EPMC10103884 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature