Influence of cytokines on early death and coagulopathy in newly diagnosed patients with acute promyelocytic leukemia.

ABSTRACT:

Introduction

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) with a better prognosis. But early death (ED) rate remains high. APL patients are simultaneously accompanied by coagulopathy and hyperinflammation at the onset. It is not known what effects cytokines have on ED and coagulopathy in these patients. Therefore, the purposes of this study are to explore the clinical differences between APL and other types of AML, the link between cytokines and coagulopathy in newly diagnosed APL, and their roles in the ED for APL.

Methods

This study retrospectively collected the information of 496 adult patients with AML (age ≥14 years at admission) newly diagnosed in the First People's Hospital of Yunnan Province between January 2017 to February 2022, in

SUBMITTER: Zhao S 

PROVIDER: S-EPMC10103902 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature