MRBEE: A novel bias-corrected multivariable Mendelian Randomization method.

ABSTRACT: Mendelian randomization (MR) is an instrumental variable approach used to infer causal relationships between exposures and outcomes and can apply to summary data from genome-wide association studies (GWAS). Since GWAS summary statistics are subject to estimation errors, most existing MR approaches suffer from measurement error bias, whose scale and direction are influenced by weak instrumental variables and GWAS sample overlap, respectively. We introduce MRBEE (MR using Bias-corrected Estimating Equation), a novel multivariable MR method capable of simultaneously removing measurement error bias and identifying horizontal pleiotropy. In simulations, we showed that MRBEE is capable of effectively removing measurement error bias in the presence of weak instrumental variables and sample overla

SUBMITTER: Lorincz-Comi N 

PROVIDER: S-EPMC10103949 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature